Charlie's Challenge Room at the University of Portsmouth
Research scientist at the Institute of Neurology
Eastbourne College fundraising cheque
Research Projects & Fund Raising

Having raised the money it is of equal importance that it is spent on the best worthwhile research projects.

Charlie’s Challenge is fortunate in that it uses a Medical and Scientific Panel comprising a team of experts in brain tumours from around the United Kingdom.

All applications for brain tumour research projects are examined by the panel and graded in order of importance so that Charlie’s Challenge is able to select the best research projects to fund.

The charity is continuing its investment in the Brain Tumour Research centre at the University of Portsmouth and together with Ali's Dream, Headcase and Brain Tumour Research granted £500,000 which has also enabled the appointment of a Senior Research Fellow and three PhD students to compliment Professor Pilkington's team.

2010 saw Charlie's Challenge collaborating with sister charity, Ali's Dream, to pave the way for the establishment of a brain tumour research Centre of Excellence at the University of Portsmouth.   Both charities have committed £400,000 between them with a further £100,000 being added by umbrella charity, Brain Tumour Research.  This is phase 1 of a plan to raise £1,000,000 which will ensure that the long-term aim of the University of Portsmouth to find a solution to brain tumours is maintained and secured.  

Charlie's Challenge teamed up with fellow Brain Tumour Research member, Ali's Dream in 2006 to form a joint funding initiative pooling their financial resources. Fourteen research applications were vetted by their Scientific & Medical Panel made up of experts in the paediatric brain tumour field. In January 2007, following the panel's recommendations, Charlie's Challenge and Ali's Dream agreed to fund 5 new research projects totalling £400,000. Two of these were carried out at the University of Portsmouth over a three year period. Another three year project was carried out at the University of Nottingham. A twelve month study was approved for The Royal Marsden and a two year research project into medulloblastomas was undertaken at Barts and The London.

In September 2005, a successful sponsored bicycle enabled the University of Portsmouth to buy £200,000 worth of vital research equipment for its brain tumour research unit.

In March of 2005, the charity agreed to co-fund the purchase of a microwave peptide synthesiser for the brain tumour research unit at the University of Wolverhampton. It will investigate the use of targeted cell penetrating peptides to deliver toxins to medulloblastoma cells in vitro.
It is hoped that this pre-clinical study will lead to the development of new CPP-toxin conjugates that will be clinically effective in delaying or abolishing the need to administer craniospinal irradiation especially in younger children with medulloblastoma.

In 2004, Charlie's Challenge joined an alliance with four other brain tumour charities, which created the biggest initiative ever seen in the laboratory based brain tumour research field. Through collective fundraising, ten new research projects were sponsored throughout the whole country at a cost of £1.5 million.

Charlie's Challenge is also proud to have helped finance a £200,000 time-lapse microscopy facility at the University of Portsmouth in 2003.

Charlie's Challenge joined forces with sister charity, The Samantha Dickson Research Trust in 2001, to co-fund a three year research project costing £140,000. It was undertaken by Dr SC Clifford at the University of Newcastle to develop new therapies for an improved success rate in the treatment of paediatric medulloblastomas.

Having originally contributed to various projects, in 2000, Charlie's Challenge agreed to fund an entire three year £120,000 project with the University Department of Neurosurgery, Institute of Neurology, University College, National Hospital for Neurology and Neurosurgery. The research team were involved in developing effective new therapies for the treatment of ependymonas, the third most common of the many types of brain tumours in children.


Charlie's Challenge carries no administration costs at all.
Every penny raised is spent on vital research.

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